Teaching-Learning Materials Β· Topic 1 Β· AyUG-RB Β· II BAMS (NCISM)
Definition, chronological development, significance and scope of Rasashastra and Bhaishajya Kalpana. Concept of Rasashala, Rasa-mandapa and Bheshajagara. Concept of Rasa-Rasayana. Briefing on Indians being first to prepare metal-based medicines, and recent developments in Ayurvedic Pharmaceuticals.
1Explain historical evolution of Ayurvediya aushadhi nirman and Rasashastra.
2Describe about contribution of Nagarjuna Acharya to Rasashastra.
3Enlist important classical texts of Rasashastra and describe their unique features in short.
4Describe structure of Pharmacy and enlist formulations prepared in pharmacy, after visiting the unit of teaching pharmacy of own campus.
5Describe Recent development in Ayurvedic Pharmaceuticals viz. new dosage forms, pharmaceutical modification techniques.
6Define Rasa and Rasayana and describe difference between Rasa and Rasayana.
7Justify design of ancient Rasashala.
Definition and importance of Paribhasha; word derivations (Aushadha, Bheshaja, Kalpana, Kashaya, Pancha Kashaya Yoni, Samskara); Dravya/Varga Paribhasha (classical & English names, chemical composition β Rasa, Maharasa, Uparasa, and controversial/artificial/substitute drug categories); Prakriya Paribhasha (Shodhana, Marana, Amrutikarana, Druti, Parada Samskara); Pramanikarana Paribhasha / standardization terms (Bhasma Pariksha); Puraka Paribhasha; and Mana-Paribhasha (classical & modern units of measurement).
1Explain the term Paribhasha and its importance in Ayurvediya Aushadhi Nirmana.
2Describe the terms Aushadha, Bheshaja, Kalpana, Kashaya, Kashaya Yoni, Samskara β based on their word derivations.
3Enlist sequentially names of all drugs classified in the varga (group). Recite shlokas of Maharasa, Uprasa, Sadharana Rasa Varga from Rasaratnasamuchchaya.
4Enlist and discuss Sandigdha, Krutrima, Pratinidhi and Anupalabdha dravya.
5Describe the definition of the term Shodhana. Explain with examples different techniques used for the procedures of Shodhana.
6Explain the term Marana and describe its types with examples.
7Enlist all relevant prakriya paribhasha of Amrutikarana, Lohitikarana, Sattvapatana, Druti and discuss with examples.
8Recite sequentially names of Parada Ashta Samskara. Explain the terms Jarana, Murchchhana and cite types with examples. Compare Jarana and Murchchhana.
9Identify names of Parada Bandhas.
10Describe Grahyagrahya parameters used for selection of Rasadravyas.
11Illustrate all Bhasma pariksha as per classical description.
12Define the word Siddhilakshani. Recite examples of classical siddhilakshani. Interpret its rationality.
13Recognise and discuss Dhanvantari Bhaga and Rudra Bhaga.
14Explain importance of Mana-paribhasha and classical types of Mana. Recall charts of Mana.
Methodology: Divide the batch into groups of 4β5 students. Each group picks a task written on a paper slip and completes it:
15Categorize parameters of Drug Standardization and develop a checklist for assessment of quality of rasadravyas.
16Explain value of selection of genuine raw material.
17Explain importance of ethical practices for drug processing (Shodhana, Marana).
18Discuss and justify importance of Bhasma Pariksha.
19Explain value of keen and accurate application of weights and measures in Ayurvediya Aushadhi Nirmana.
Dravya Sangraha and Samrakshana β time of drug collection, general rules, specific timing for specific plant parts, time of day, collection of Pranija Dravya, place of collection (Bhumi Mahabhuta predominance), places to avoid, stage of collection, Dwiguna Mana Ganana (rule of duplication), Ardra & Shushka Dravya Mana, collection method & preservation. Rasa, Guna, Virya, Vipaka, Prabhava; Anukta-Visheshokta grahana; Aushadha Namakarana (naming); Sevana Kala (time of administration); Saveeryata Avadhi (shelf life); Aushadha Matra (dosage/posology); Anupana & Sahapana; Yogika Dravya Siddhanta (drug combination).
1Elaborate fundamental principles of Ayurvediya Aushadhi Nirmana along with their classical references and discuss their application with classical examples of various kalpas.
2Explain Dravya Samgraha Vidhi. Explain types of Bhumi Desha and types of drugs to be collected from a particular place & places from where Dravya should not be collected.
3Describe time of Dravya collection and explain rationality behind it.
4Enlist parts of Sthavara & Jangama Dravyas used for Ayurvediya Aushadhi Nirmana.
5Define Samskara. Discuss role of Samskara in Ayurvediya Aushadhi Nirmana along with various examples.
6Describe Ardra β Shushka Dravya & Anukta β Visheshokta Dravya collection principles.
7Describe importance of Kalpa Sevan Matra. Explain factors considered for deciding dosage of any drug (Ayurvedic as well as modern medicine principles). Describe Posology.
8Explain Saveeryata Avadhi (Shelf life) of Ayurvedic dosage forms.
9Discuss Yogika Dravya Siddhanta (Drug combination).
10Justify Aushadhi Kalpa Namakarana Siddhanta (naming principle) with examples.
Principles involved, currently used Yantras, their correlation and utility, and instruments used in large-scale production β Dola, Valuka, Puta, Khalwa, Patana, Darvika, Ulukhala, Patala, Kupi, Arkapatana, Pithara, Sharava, Palika, Sthali, Swedana, and Vidyadhara Yantra. Modern machinery β Grinder, Disintegrator, Pulverizer, Powder Mixer, Mechanical Sifter, Ball Mill, Granulator, Dryer, Tablet Compressing Machine, Pills Making Machine, Coating Pan, Polishing Pan, End Runner, Edge Runner, Capsule Filling Machine, Ointment Mixer, Tube Filling Machine, Sieves & Meshes, Liquid Filling Machine, Distillation Plant, Strip Packing Machine, Pouch Filling Machine, and Pyrometer.
1Choose and record contemporary machines used in Ayurvedic drug preparation.
2Discuss the pharmaceutical use of Distillation apparatus, Ball Mill, Pulveriser, End Runner, Edge Runner, Tablet compression machine, Capsule filling machine, Pouch filling machine, and Liquid filling machine in Ayurvediya Aushadhi Nirmana.
3Describe the principles behind construction and working of the classical Yantras used for Ayurvediya Aushadhi Nirmana.
4Enlist categorical information about the following Yantras in charts β Ulukhal Yantra, Patan Yantra, Jarana Yantra, Patala Yantra, and Swedana Yantra.
5Enlist Ayurvediya Aushadhi Kalpana and equipments/yantras/machines used for preparation of each kalpana.
Principle involved, importance of temperature, currently used heating devices, quantum of heat, and instruments used in large-scale production. Types of Puta β Chandra, Surya, Maha, Gaja, Varaha, Kukkuta, Kapota, Lavaka, Budhar, Gorvara, Valuka, Kumbha/Bhanda Puta. Musha (Samanya Musha, Crucibles β Silica), Mudra, Sandhi Bandhan material. Koshthi (Chullika, Angar Koshthi, Satwapatan, Bhrashtri), Gas Stove, Hot Plate, Heating Mantle, Induction Stove, Hot Air Oven, Muffle Furnace (horizontal & vertical). Heating material β solid (Kashtha, coal, Kshara, Lavana, Valuka, Shakrit, Dhanya) and Drava (Jala/steam, Taila); indirect heating (Dhanya Rashi, Bhugarbha Sthapana).
1Describe the term Yantra and enlist yantras described in classics useful for aushadhi nirmana.
2Define the term Puta and recite its classical explanation.
3Produce categorical information (size of pit, number of cowdung cakes, use, etc.) about the following Putas: Mahaputa, Gajaputa, Varahputa, Kukkutaputa, Kapotputa, Lavakputa, Kumbhaputa, Bhandaputa, Valukaputa and Bhudharputa.
4Recognise the principles behind construction and working of the classical Putas.
5Review the temperature pattern of various Putas by referring research articles.
6Compile names and significance of temperature measuring devices with reference to Puta.
7Enlist the specific Puta used for a particular Bhasma Nirmana.
8Enlist various devices used for heating during Ayurvediya Aushadhi Nirmana.
9Enlist constituents needed for Samanya Musha Nirmana.
10Define the term Musha and describe uses of various types of Musha.
11Enlist and discuss the material used for Sandhi Bandhan (while using Sharava and Kachakupi).
12Identify and record the types of Crucibles.
13Interpret the effect of heat transformation in the material subjected to heating through Musha.
14Recall Pakaj Utpatti Siddhant and interpret it for Agni Sannikarsha Sanskara.
15Explain the pharmaceutical use of the Hot plate, heating mantle, induction stove, hot air oven, muffle furnace (horizontal and vertical type).
16Describe types of Koshthi and their uses.
17Describe the current trends in heat transfer devices β e.g. steam jacketed heating device, programmed muffle furnace, programmed furnace for Parpati/Pottali preparation.
18Assess and interpret the effect of fuel in quantum of heat given (time and temperature).
19Enlist various fuels used for heating for estimation of their heat value.
20Analyse and appraise use of proper heating device and fuels used for Ayurvediya Aushadhi Nirmana.
Definition, classification with suitable examples, reference ingredients, quantity, method of preparation, principle involved, instruments used in small & large scale production, Siddhi Lakshana, storage, shelf life, and modern aspects of the following Panchavidha Kashaya Kalpana (primary dosage forms): Swarasa, Kalka, Kwatha, Hima, Phanta. Upakalpana (secondary dosage forms) β Kalka: Churna Kalpana; Kwatha: Pramathya Kalpana, Paniya Kalpana, Ushnodaka, Ksheera Paka Kalpana, Laksha Rasa, Mamsa Rasa; Hima: Mantha Kalpana, Udaka Kalpana, Panaka Kalpana; Phanta: Arka.
1Define with synonyms and classify different varieties of the dosage form in Ayurvediya Aushadhi Nirmana.
2Describe methods of preparation of the dosage form along with the principles of extraction, concentration and dilution, etc.
3Explain in detail about the Standard Operating Procedure (SOP) of each Kalpana.
4Enlist details of the applications/administration (Samanya Matra, Anupana or Sahapana, indications and contraindications) of the dosage form with various examples.
5Assess and discuss modern day development and market trend of the dosage form.
6Determine the advantages and disadvantages of the dosage form.
7Describe method of preparation of dosage form along with the principle involved.
8Describe meaning of the term Upakalpana. Enlist Panchavidha Kashaya Kalpana and their respective Upakalpana.
9Critically evaluate rationality behind different proportion of water used in various formulations.
Avaleha β definition, reference, essential ingredients, general method of preparation, specific rules, importance of temperature, Siddhi Lakshana, shelf life, examples (Vasavaleha, Kushmanda Avaleha), research updates, market survey. Sneha Kalpana β aims, definition, reference, essential ingredients, method of preparation, Gritha/Taila Murchana, Sneha Siddhi Lakshana, types of Snehapaka, Patra (Gandha Paka), cooking time duration, shelf life, examples (Phala Gritha, Ksheerabala Taila), concept of Avartana, research updates, market survey. Sandhana Kalpana β significance, classification, difference between Madhya and Shukta Kalpana, method of preparation, essential ingredients, Anukta Mana, Sandhana Vidhi, Burning Candle Test, Lime Water Test, Asava-Arishta preparation factors (patra selection, fermentation place, room temperature, Sandhana Kala, adding honey/bhasma/prakshepaka dravya), difference between Asava & Arishta, shelf life & alcohol %, examples (Draksharishta, Usheerasava), research updates, market survey. Pathya Kalpana β definition, significance, types, method of preparation of Manda, Peya, Yavagu, Vilepi, Anna/Odana Kalpana, Krushara, Yusha, Takra, Khada, Kambalika, Raga, Shadava; research updates and market survey of dietary supplements.
1Explain the basic principles involved, processing techniques, and quality control parameters used in the preparation of Avaleha Kalpana with examples, instruments used in small & large scale production, and research updates.
2Explain the basic principles involved, processing techniques, and quality control parameters used in the preparation of Sneha Kalpana with examples, instruments used in small & large scale production, the concept of Avartana, research updates, and market survey.
3Describe the significance of Sandhana Kalpana, classification, difference between Madya and Shukta Kalpana, general method of preparation, essential ingredients, Anukta Mana, Sandhana Vidhi, observations (Burning Candle Test, Lime Water Test), difference between Asava and Arishta, essential knowledge for sale and clinical practice, and research updates.
4Explain the definition and significance of Pathya, its types, and general method of preparation β Manda, Peya, Yavagu, Vilepi, Anna/Odana Kalpana, Krushara, Yusha, Takra, Khada, Kambalika, Raga, Shadava β along with related research updates and market survey of dietary supplements and nutraceuticals.
Synonyms, mineralogical identification, sources, types, Grahya-Agrahyata, Doshas, Shodhana, Marana and other processing techniques, probable physico-chemical changes, importance of temperature while processing, Yoga, and research updates of the following Must-to-Know drugs: Parada (mercury), Abhraka (Biotite Mica), Makshika (Chalcopyrite), Shilajatu (Asphaltum Punjabianum), Gandhaka (Sulfur), Gairika (Red Ochre), Kankshi (Alum), Haratala (Orpiment), Manahshila (Realgar), Kampillaka (Mallotus Philippinensis), Navasadara (Ammonium Chloride), Hingula (Red Cinnabar), Swarna (Gold), Rajata (Silver), Tamra (Copper), Loha (Iron), Mandur (Rust Iron), Vanga (Tin), Naga (Lead), Yashada (Zinc), Mukta (Pearl), Pravala (Coral), Vajra (Diamond), Kaparda (Cowries), Shukti (Oyster Shell), Shankh (Conch Shell), Godanti (Gypsum), Samudraphena (Cuttlefish Bone), Kukkutanda Twak (Hen's Eggshell), Tankana Kshara (Borax).
1Explain classical & mineralogical identification and sources of Rasadravyas.
2Discriminate types, Grahya-Agrahyata and Dosha of Rasadravya.
3Explain Shodhana and Marana and other processing techniques of the Rasa Dravya.
4Discuss probable physical and chemical changes occurring during processing and after Shodhana and Marana of Parada, Haratala, Tamra and Shankha.
5Discuss probable physical and chemical changes occurring after Bhavana, Puta and the whole process of Bhasma Nirmana from Rasadravyas.
6Enlist Kalpas prepared from these Rasadravyas and the therapeutic importance of that Rasadravya.
7Develop a checklist for identification of genuine Rasadravyas.
Synonyms, mineralogical identification, sources, types, Grahya-Agrahyata, Shodhana, Marana and other processing techniques with probable chemical reactions, importance of temperature, Yoga, and research updates of the following Desirable-to-Know drugs: Sasyaka (Peacock Ore), Kaseesa (Green Vitriol), Gauripashana (Arsenic Oxide), Trinakanta, Akika (Agate), Sudha (Limestone), Khatika, Ajashthi, Jaharmohara (Serpentine), Dugdhapashana (Talc).
1Enlist the important synonyms of Rasadravyas.
2Elaborate types, Grahya-Agrahyata and Dosha of Rasadravyas.
3Explain Shodhana, Marana and other processing techniques with probable chemical reactions. (Cognitive/Comprehension level)
4Explain Shodhana, Marana and other processing techniques with probable chemical reactions. (Evaluation level β practical application)
5Explain research updates of Kasisa, Gauripashana and Akika.
6Enlist names of Rasadravyas and important Kalpas prepared from the respective dravya. Describe therapeutic importance of that Rasadravya.
Synonyms, mineralogical identification, sources, types, Grahya-Agrahyata, Shodhana, Marana, probable chemical changes, properties, dose, Ashuddha/Apakwa Bhasma Sevanajanya Vyadhi and their Shantyupaya, Yoga, and research updates of the following Nice-to-Know drugs: Vaikrantha, Vimala (Iron Pyrite), Chapala, Rasaka, Anjana, Kankustha, Agnijara, Giri Sindura (Red Oxide of Mercury), Mriddara Shringa (Litharge), Kamsya (Bronze), Pittala (Brass), Vartaloha, Manikya (Ruby), Tarkshya (Emerald), Pushparaga (Topaz), Nilam (Sapphire), Gomeda (Zircon/Cinnamon Stone), Vaidurya (Cat's Eye), Mriga Shringa (Stag Horn), Sikata (Silica), Vyomashma (Jade), Kousheyashma (Asbestos), Badarashma (Silicate of Lime).
1Determine types, Grahya-Agrahya, properties & classical as well as mineralogical identification of Rasadravyas.
2Explain Shodhana, Marana and probable chemical changes.
3Explain research update of Badarashma.
4Enlist Rasadravyas from this group and describe important Kalpas with their therapeutic utility.
Sharkara Kalpana β general method of preparation, difference between Sharkara Kalpana and syrup, importance of temperature, precautions, confirmatory tests, packing, preservation, shelf life (e.g. Tulasi Arka Sharkara). Gudapaka β general method of preparation, temperature, precautions, confirmatory tests, packing, preservation, shelf life (e.g. Manibhadra Guda, Guda Pippali). Lavana Kalpana β general method of preparation (e.g. Narikela Lavana). Kshara Kalpana β general method of preparation, temperature, precautions, confirmatory tests, packing, preservation, shelf life (e.g. Kadali Kshara, Chincha Kshara). Ayaskriti Kalpana β general method, temperature, precautions, confirmatory tests, packing, preservation, shelf life (e.g. Ayaskriti). Lepa Kalpana β general method, temperature, precautions, confirmatory tests, packing, preservation, shelf life (e.g. Avalgunjadi Lepa, Keshavardhaka Lepa).
1Describe Sharkara Kalpana along with preparation method of Syrup. Explain therapeutic importance of prepared Sharkara Kalpana along with its shelf life.
2Describe Gudapaka preparation method with its confirmatory tests and precautions. Explain therapeutic importance of prepared Gudapaka along with its shelf life.
3Describe Kshara Kalpana preparation method with its confirmatory tests and precautions. Explain therapeutic importance of prepared Kshara Kalpana and Ksharasutra integration with the Shalya Tantra department, along with its shelf life and packaging techniques.
4Describe Ayaskriti Kalpana preparation method with its confirmatory tests and precautions. Explain therapeutic importance of prepared Ayaskriti Kalpana along with its shelf life and packaging techniques.
5Describe Lepa Kalpana preparation method with its confirmatory tests and precautions. Explain therapeutic importance of prepared Lepa Kalpana, its integration with the Kayachikitsa and Panchakarma departments, along with its shelf life and packaging techniques.
Introduction, definition, importance, types, procedure, necessary equipment, and shelf life of the four Rasayana preparation forms β Kharaliya Rasayana (e.g. Shwasakuthara Rasa, Vatavidhwansana Rasa), Parpati Rasayana (e.g. Loha Parpati, Sudha Parpati), Kupipakwa Rasayana (e.g. Rasasindura, Rasa Karpura), and Pottali Rasayana (e.g. Tamragarbha Pottali, Lohagarbha Pottali).
Method of Activity (Survey): Divide students into 5 groups, each centered on formulations containing Swarna Bhasma as an ingredient:
1Describe importance and unique features of Chaturvidha Rasayana β Kharaliya Rasayana, Parpati Rasayana, Kupipakwa Rasayana & Pottali Rasayana.
2Explain definition, types and method of preparation of Chaturvidha Rasayana.
3Explain shelf-life of Chaturvidha Rasayana.
4Describe chemical changes occurring during the preparation of Chaturvidha Rasayana and its impact on pharmacological action of Chaturvidha Rasayana.
5Explain law of Definite Proportion and the proportion of Mercury and Sulphur needed for preparation of Sulphide of Mercury in Chaturvidha Rasayana.
Cosmetics β brief introduction to cosmetic formulation and regulatory provisions, plant layout and other factory requirements, manufacturing process, most commonly used cosmetic raw materials, control of microbial contamination, quality control of cosmetics, skin sensitization/sensitivity testing, in-vitro tests for skin irritation, QC of raw materials/intermediates/finished products, and stability of cosmetics. Introduction to Dosage Forms β classification of dosage forms (solid, liquid, and semisolid) and the need for dosage forms.
1Discuss the classification of different dosage forms.
2Explain the need of different dosage forms.
3Appreciate Ayurvedic cosmetic products.
4Choose and record the contemporary machineries used in the manufacture of cosmetics.
5Enlist Quality Control parameters of cosmetics preparations.
Brief overview of the Drug and Cosmetics Act 1940 and Rules 1945 β import, manufacture, sale, distribution of drugs and cosmetics, standards of quality, misbranded/adulterated/spurious drugs and cosmetics as amended from time to time. New Acts related to Drugs and Devices. Good Manufacturing Practices (GMP) of ASU Drugs in accordance with Schedule-T, Food Safety and Standards Authority of India (FSSAI), and FDA-Approval Drugs.
1Explain the legal and regulatory aspects of manufacturing and sale of Ayurvedic drugs.
2Describe acts and rules mentioned in Drug & Cosmetic Act 1940 & Rule 1945 and their relevance to Ayurvedic, Siddha, Unani (ASU) drugs.
3Discuss the guidelines of Food Safety and Standards Authority of India (FSSAI) and FDA.
4Determine the principles and practice of establishment of an Ayurvedic pharmacy.
5Explain long forms of these abbreviations β FSSAI, FDA, CCRAS, DCGI, CDSCO.
6Discuss ethical aspect of large scale drug preparation in Ayurvedic Pharmacies.
Created by Vd. Chaitanya S Badami, BAMS, MD